InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Il13

Summary

InnateDB Gene

IDBG-172064.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il13

Gene Name

interleukin 13

Synonyms

Il-13

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020383

Encoded Proteins

IDBP-172066

interleukin 13

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22154382

Il13 dampens the innate immune response in airway epithelial cells via Irak3-mediated inhibition of Tlr2 signalling. (Demonstrated in human)

PMID 24613091

IL13 produced by activated innate lymphoid cells type 2 (ILC2s) is critical for promoting the migration of activated lung dendritic cells to the draining lymph node, and in the differentiation of naive CD4+ T cells into Th2 cells

InnateDB Annotation from Orthologs

Summary

PMID 21097505

[Homo sapiens] IL13 is a pro-M2/Th2 cytokine that induces alternative activation of macrophages. IL13 associates with IL13RA1 to activate the transcription factor STAT6.

PMID 22154382

[Homo sapiens] IL13 dampens the innate immune response in airway epithelial cells via IRAK3-mediated inhibition of TLR2 signalling.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169194:
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:53631324-53634702

Strand

Reverse strand

Band

B1.3

Transcripts

ENSMUST00000020650

ENSMUSP00000020650

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	0
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005126	cytokine receptor binding
GO:0005144	interleukin-13 receptor binding
GO:0005515	protein binding

Biological Process

GO:0001774	microglial cell activation
GO:0002639	positive regulation of immunoglobulin production
GO:0006955	immune response
GO:0009612	response to mechanical stimulus
GO:0010155	regulation of proton transport
GO:0030890	positive regulation of B cell proliferation
GO:0032496	response to lipopolysaccharide
GO:0032723	positive regulation of connective tissue growth factor production
GO:0033861	negative regulation of NAD(P)H oxidase activity
GO:0035094	response to nicotine
GO:0042526	positive regulation of tyrosine phosphorylation of Stat6 protein
GO:0043032	positive regulation of macrophage activation
GO:0043270	positive regulation of ion transport
GO:0045087	innate immune response (InnateDB)
GO:0045471	response to ethanol
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050714	positive regulation of protein secretion
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0071260	cellular response to mechanical stimulus
GO:0071345	cellular response to cytokine stimulus
GO:0071635	negative regulation of transforming growth factor beta production
GO:1901215	negative regulation of neuron death
GO:2000231	positive regulation of pancreatic stellate cell proliferation