Homo sapiens Gene: IL13
Summary
InnateDB Gene IDBG-42599.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL13
Gene Name interleukin 13
Synonyms IL-13; P600;
Species Homo sapiens
Ensembl Gene ENSG00000169194
Encoded Proteins
interleukin 13
interleukin 13
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
IL13 is a pro-M2/Th2 cytokine that induces alternative activation of macrophages. IL13 associates with IL13RA1 to activate the transcription factor STAT6.
IL13 dampens the innate immune response in airway epithelial cells via IRAK3-mediated inhibition of TLR2 signalling.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Il13 dampens the innate immune response in airway epithelial cells via Irak3-mediated inhibition of Tlr2 signalling. (Demonstrated in human)
[Mus musculus] IL13 produced by activated innate lymphoid cells type 2 (ILC2s) is critical for promoting the migration of activated lung dendritic cells to the draining lymph node, and in the differentiation of naive CD4+ T cells into Th2 cells
Entrez Gene
Summary This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:132656263-132661110
Strand Forward strand
Band q31.1
Transcripts
ENST00000304506 ENSP00000304915
ENST00000468334
ENST00000459878
ENST00000487267
ENST00000462480
ENST00000617259 ENSP00000479835
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 7 [view]
Protein-DNA 14 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 5 [view]
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005144 interleukin-13 receptor binding
GO:0005515 protein binding
Biological Process
GO:0001774 microglial cell activation
GO:0002639 positive regulation of immunoglobulin production
GO:0006928 cellular component movement
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0009612 response to mechanical stimulus
GO:0010155 regulation of proton transport
GO:0030890 positive regulation of B cell proliferation
GO:0032496 response to lipopolysaccharide
GO:0032723 positive regulation of connective tissue growth factor production
GO:0033861 negative regulation of NAD(P)H oxidase activity
GO:0035094 response to nicotine
GO:0042526 positive regulation of tyrosine phosphorylation of Stat6 protein
GO:0043032 positive regulation of macrophage activation
GO:0043270 positive regulation of ion transport
GO:0045087 innate immune response (InnateDB)
GO:0045471 response to ethanol
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050714 positive regulation of protein secretion
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0071260 cellular response to mechanical stimulus
GO:0071345 cellular response to cytokine stimulus
GO:0071635 negative regulation of transforming growth factor beta production
GO:1901215 negative regulation of neuron death
GO:1901247 negative regulation of lung ciliated cell differentiation
GO:1901251 positive regulation of lung goblet cell differentiation
GO:2000231 positive regulation of pancreatic stellate cell proliferation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0009897 external side of plasma membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
IL4 pathway
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Asthma pathway
INOH
GPCR signaling pathway
JAK STAT pathway and regulation pathway
IL-13 signaling pathway
PID BIOCARTA
Gata3 participate in activating the th2 cytokine genes expression [Biocarta view]
PID NCI
IL12 signaling mediated by STAT4
Glucocorticoid receptor regulatory network
Cross-References
SwissProt
TrEMBL Q4VB50 Q4VB53
UniProt Splice Variant
Entrez Gene 3596
UniGene
RefSeq NM_002188
HUGO HGNC:5973
OMIM 147683
CCDS CCDS4157
HPRD
IMGT
EMBL BC096138 BC096141
GenPept AAH96138 AAH96141
RNA Seq Atlas 3596