|Homo sapiens Gene: IL13|
|Last Modified||2012-02-14 [Report errors or provide feedback]|
|Gene Name||interleukin 13|
|Synonyms||ALRH; BHR1; IL-13; P600;|
IL13 is a pro-M2/Th2 cytokine that induces alternative activation of macrophages. IL13 associates with IL13RA1 to activate the transcription factor STAT6.
IL13 dampens the innate immune response in airway epithelial cells via IRAK3-mediated inhibition of TLR2 signalling.
|InnateDB Annotation from Orthologs|
[Mus musculus] Il13 dampens the innate immune response in airway epithelial cells via Irak3-mediated inhibition of Tlr2 signalling. (Demonstrated in human)
[Mus musculus] IL13 produced by activated innate lymphoid cells type 2 (ILC2s) is critical for promoting the migration of activated lung dendritic cells to the draining lymph node, and in the differentiation of naive CD4+ T cells into Th2 cells
[Mus musculus] Neutrophils in helminth-infected mice show a distinct transcriptional profile and promote alternatively activated M2 macrophage polarization through secretory factors including Il13.
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 5:131991955-131996802|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Fc epsilon RI signaling pathway pathway
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
JAK STAT pathway and regulation pathway
IL-13 signaling pathway
GPCR signaling pathway
IL12 signaling mediated by STAT4
Glucocorticoid receptor regulatory network
|UniProt Splice Variant|
|EMBL||AC004039 AF043334 AF377331 BC096138 BC096139 L06801 U10307 U31120 X69079|
|GenPept||AAA36107 AAA83738 AAB01681 AAC03535 AAH96138 AAH96139 AAK53823 CAA48823 CAA48824|
|RNA Seq Atlas||3596|