|Homo sapiens Gene: IL13|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||interleukin 13|
IL13 is a pro-M2/Th2 cytokine that induces alternative activation of macrophages. IL13 associates with IL13RA1 to activate the transcription factor STAT6.
IL13 dampens the innate immune response in airway epithelial cells via IRAK3-mediated inhibition of TLR2 signalling.
|InnateDB Annotation from Orthologs|
[Mus musculus] Il13 dampens the innate immune response in airway epithelial cells via Irak3-mediated inhibition of Tlr2 signalling. (Demonstrated in human)
[Mus musculus] IL13 produced by activated innate lymphoid cells type 2 (ILC2s) is critical for promoting the migration of activated lung dendritic cells to the draining lymph node, and in the differentiation of naive CD4+ T cells into Th2 cells
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 5:132656263-132661110|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
Fc epsilon RI signaling pathway pathway
GPCR signaling pathway
JAK STAT pathway and regulation pathway
IL-13 signaling pathway
IL12 signaling mediated by STAT4
Glucocorticoid receptor regulatory network
|UniProt Splice Variant|
|EMBL||AC004039 AF043334 AF377331 BC096138 BC096139 BC096141 L06801 U10307 U31120 X69079|
|GenPept||AAA36107 AAA83738 AAB01681 AAC03535 AAH96138 AAH96139 AAH96141 AAK53823 CAA48823 CAA48824|
|RNA Seq Atlas||3596|