Version 5.4
Mus musculus Gene: Cd276
Summary
InnateDB Gene IDBG-172080.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd276
Gene Name CD276 antigen
Synonyms 6030411F23Rik; AU016588; B7h3; B7RP-2
Species Mus musculus
Ensembl Gene ENSMUSG00000035914
Encoded Proteins
IDBP-172082
CD276 antigen
IDBP-626715
CD276 antigen
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103855:
The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:58524300-58555132
Strand Reverse strand
Band B
Transcripts
ENSMUST00000039788 ENSMUSP00000042681
ENSMUST00000165365 ENSMUSP00000129418
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0030501 positive regulation of bone mineralization
GO:0042102 positive regulation of T cell proliferation
GO:0042110 T cell activation
GO:0042130 negative regulation of T cell proliferation
GO:0045077 negative regulation of interferon-gamma biosynthetic process
GO:0045078 positive regulation of interferon-gamma biosynthetic process
GO:0045085 negative regulation of interleukin-2 biosynthetic process
GO:0045669 positive regulation of osteoblast differentiation
GO:0050728 negative regulation of inflammatory response
GO:0050776 regulation of immune response
GO:1900042 positive regulation of interleukin-2 secretion
Cellular Component
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000103855
View Gene Order
ENSBTAG00000019734
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Cross-References
SwissProt Q8VE98
TrEMBL A6MDC5
UniProt Splice Variant
Entrez Gene 102657
UniGene Mm.396580
RefSeq NM_133983
OMIM
CCDS CCDS23244
HPRD
IMGT
MGI ID MGI:2183926
MGI Symbol Cd276
EMBL AK155114 AY190318 BC019436 BC056608 DQ832276
GenPept AAH19436 AAH56608 AAP04007 ABI30210 BAE33058
RNA Seq Atlas 102657

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca