Version 5.4
Homo sapiens Gene: CD276
Summary
InnateDB Gene IDBG-21197.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD276
Gene Name CD276 molecule
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000103855
Encoded Proteins
IDBP-21199
CD276 molecule
IDBP-21201
CD276 molecule
IDBP-599091
CD276 molecule
IDBP-587048
CD276 molecule
IDBP-593119
CD276 molecule
IDBP-599220
CD276 molecule
IDBP-602297
CD276 molecule
IDBP-592479
CD276 molecule
IDBP-595372
CD276 molecule
IDBP-600214
CD276 molecule
IDBP-594718
CD276 molecule
IDBP-588548
CD276 molecule
IDBP-747622
IDBP-746018
IDBP-747301
IDBP-746340
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:73683966-73714518
Strand Forward strand
Band q24.1
Transcripts
ENST00000318443 ENSP00000320084
ENST00000318424 ENSP00000320058
ENST00000560786 ENSP00000452649
ENST00000558689 ENSP00000453907
ENST00000537340 ENSP00000441087
ENST00000561213 ENSP00000452736
ENST00000560928 ENSP00000453330
ENST00000561416 ENSP00000452905
ENST00000560995 ENSP00000453336
ENST00000561260 ENSP00000452669
ENST00000561176 ENSP00000453014
ENST00000557951
ENST00000559073 ENSP00000453842
ENST00000559978
ENST00000559465
ENST00000564751 ENSP00000454940
ENST00000567189 ENSP00000455366
ENST00000563584 ENSP00000454258
ENST00000567582 ENSP00000456657
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0006955 immune response
GO:0008283 cell proliferation
GO:0030501 positive regulation of bone mineralization
GO:0042102 positive regulation of T cell proliferation
GO:0042110 T cell activation
GO:0042130 negative regulation of T cell proliferation
GO:0045077 negative regulation of interferon-gamma biosynthetic process
GO:0045078 positive regulation of interferon-gamma biosynthetic process
GO:0045085 negative regulation of interleukin-2 biosynthetic process
GO:0045669 positive regulation of osteoblast differentiation
GO:0050728 negative regulation of inflammatory response
GO:0050776 regulation of immune response
GO:1900042 positive regulation of interleukin-2 secretion
Cellular Component
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035914
View Gene Order
ENSBTAG00000019734
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.737107 Hs.743526 Hs.77873
RefSeq NM_001024736 NM_025240 XM_005254699 XM_005254700
HUGO
OMIM
CCDS CCDS10251 CCDS32288
HPRD 05756
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca