Version 5.4
| Homo sapiens Gene: CLEC4E | |||||||||||||
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| Summary | |||||||||||||
| InnateDB Gene | IDBG-17212.6 | ||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
| Gene Symbol | CLEC4E | ||||||||||||
| Gene Name | C-type lectin domain family 4, member E | ||||||||||||
| Synonyms | |||||||||||||
| Species | Homo sapiens | ||||||||||||
| Ensembl Gene | ENSG00000166523 | ||||||||||||
| Encoded Proteins |
C-type lectin domain family 4, member E
C-type lectin domain family 4, member E
C-type lectin domain family 4, member E
C-type lectin domain family 4, member E
C-type lectin domain family 4, member E
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| Protein Structure | |||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
| InnateDB Annotation | |||||||||||||
| Summary |
CLEC4E, a C-type lectin receptor, is a pattern recognition receptor critical for immune responses to fungi. CLEC4E is coupled to SYK kinase and signals via CARD9 to activate NFKB, which in turns induces both innate and adaptive immunity.
Glycerol monomycolate is a unique ligand for CLEC4E (Mincle).
Cholesterol crystals are an endogenous ligand for CLEC4E and their binding activates innate immune responses.
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| InnateDB Annotation from Orthologs | |||||||||||||
| Summary |
[Mus musculus] Clec4e, a C-type lectin receptor, is a pattern recognition receptor critical for immune responses to fungi. Clec4e is coupled to Syk kinase and signals via Card9 to activate NFKB, which in turns induces both innate and adaptive immunity.
[Mus musculus] The expression of Clec4e (Mincle) and its downstream signal phospho-Syk/Syk increases after cerebral ischemia and reperfusion.
[Mus musculus] Clec4d is an inducible myeloid-expressed C-type lectin receptor, whose expression is tightly linked to that of Clec4e.
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| Entrez Gene | |||||||||||||
| Summary |
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||
| Type | Protein coding | ||||||||||||
| Genomic Location | Chromosome 12:8533305-8540963 | ||||||||||||
| Strand | Reverse strand | ||||||||||||
| Band | p13.31 | ||||||||||||
| Transcripts |
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| Interactions | |||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Cross-References | |||||||||||||
| SwissProt | |||||||||||||
| TrEMBL | F8WFA1 | ||||||||||||
| UniProt Splice Variant | |||||||||||||
| Entrez Gene | 26253 | ||||||||||||
| UniGene | Hs.236516 | ||||||||||||
| RefSeq | NM_014358 | ||||||||||||
| HUGO | HGNC:14555 | ||||||||||||
| OMIM | 609962 | ||||||||||||
| CCDS | CCDS8594 | ||||||||||||
| HPRD | 13075 | ||||||||||||
| IMGT | |||||||||||||
| EMBL | AC092746 | ||||||||||||
| GenPept | |||||||||||||
| RNA Seq Atlas | 26253 | ||||||||||||