InnateDB Protein
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IDBP-17214.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CLEC4E
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Protein Name
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C-type lectin domain family 4, member E
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000299663
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InnateDB Gene
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IDBG-17212 (CLEC4E)
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Protein Structure
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Function |
C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B. {ECO:0000269PubMed:18509109}.
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Subcellular Localization |
Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001304
C-type lectin
IPR002353
Type-2 ice-structuring protein
IPR016187
C-type lectin fold
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PFAM |
PF00059
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PRINTS |
PR00356
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PIRSF |
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SMART |
SM00034
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TIGRFAMs |
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Modification |
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SwissProt |
Q9ULY5
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PhosphoSite |
PhosphoSite-Q9ULY5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
26253
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UniGene |
Hs.236516
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RefSeq |
NP_055173
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HUGO |
HGNC:14555
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OMIM |
609962
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CCDS |
CCDS8594
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HPRD |
13075
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IMGT |
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EMBL |
AB024718
AC092746
AK312671
AY358499
BC000715
CH471116
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GenPept |
AAH00715
AAQ88863
BAA83755
BAG35553
EAW88618
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