InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gata4

Summary

InnateDB Gene

IDBG-172452.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gata4

Gene Name

GATA binding protein 4

Synonyms

Gata-4

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021944

Encoded Proteins

IDBP-172454

GATA binding protein 4

IDBP-401051

GATA binding protein 4

IDBP-401050

GATA binding protein 4

IDBP-538205

GATA binding protein 4

IDBP-534579

GATA binding protein 4

IDBP-537190

GATA binding protein 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21971825

Gata4 activates the transcription of hepcidin antimicrobial peptide in hepatocytes. Friend of GATA (FOG)-proteins ZFPM1 and ZFPM2 moderate this transcription by suppressing the GATA transactivation of hepcidin promoter. (Demonstrated in human)

InnateDB Annotation from Orthologs

Summary

PMID 21971825

[Homo sapiens] GATA4 activates the transcription of hepcidin antimicrobial peptide in hepatocytes. Friend of GATA (FOG) proteins, ZFPM1 and ZFPM2, moderate this transcription by suppressing the GATA transactivation of hepcidin promoter.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136574:
This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:63198922-63271692

Strand

Reverse strand

Band

Transcripts

ENSMUST00000067417	ENSMUSP00000066927
ENSMUST00000118022	ENSMUSP00000113891
ENSMUST00000121312	ENSMUSP00000113451
ENSMUST00000132122	ENSMUSP00000121008
ENSMUST00000137244	ENSMUSP00000114279
ENSMUST00000156782	ENSMUSP00000114369

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	47 [view]
Protein-Protein	34 [view]
Protein-DNA	13 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001076	RNA polymerase II transcription factor binding transcription factor activity
GO:0001158	enhancer sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0033613	activating transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0051525	NFAT protein binding
GO:0070410	co-SMAD binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001702	gastrulation with mouth forming second
GO:0001706	endoderm formation
GO:0001947	heart looping
GO:0003007	heart morphogenesis
GO:0003151	outflow tract morphogenesis
GO:0003181	atrioventricular valve morphogenesis
GO:0003190	atrioventricular valve formation
GO:0003192	mitral valve formation
GO:0003195	tricuspid valve formation
GO:0003197	endocardial cushion development
GO:0003215	cardiac right ventricle morphogenesis
GO:0003229	ventricular cardiac muscle tissue development
GO:0003279	cardiac septum development
GO:0003281	ventricular septum development
GO:0003289	atrial septum primum morphogenesis
GO:0003290	atrial septum secundum morphogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007267	cell-cell signaling
GO:0007283	spermatogenesis
GO:0007507	heart development
GO:0008584	male gonad development
GO:0009612	response to mechanical stimulus
GO:0010468	regulation of gene expression
GO:0010507	negative regulation of autophagy
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0014898	cardiac muscle hypertrophy in response to stress
GO:0023019	signal transduction involved in regulation of gene expression
GO:0030509	BMP signaling pathway
GO:0030513	positive regulation of BMP signaling pathway
GO:0032526	response to retinoic acid
GO:0035050	embryonic heart tube development
GO:0035054	embryonic heart tube anterior/posterior pattern specification
GO:0035239	tube morphogenesis
GO:0035914	skeletal muscle cell differentiation
GO:0036302	atrioventricular canal development
GO:0042493	response to drug
GO:0043627	response to estrogen
GO:0045087	innate immune response (InnateDB)
GO:0045766	positive regulation of angiogenesis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048557	embryonic digestive tract morphogenesis
GO:0048598	embryonic morphogenesis
GO:0048617	embryonic foregut morphogenesis
GO:0048738	cardiac muscle tissue development
GO:0051891	positive regulation of cardioblast differentiation
GO:0055007	cardiac muscle cell differentiation
GO:0060008	Sertoli cell differentiation
GO:0060043	regulation of cardiac muscle cell proliferation
GO:0060045	positive regulation of cardiac muscle cell proliferation
GO:0060070	canonical Wnt signaling pathway
GO:0060290	transdifferentiation
GO:0060395	SMAD protein signal transduction
GO:0060413	atrial septum morphogenesis
GO:0060425	lung morphogenesis
GO:0060464	lung lobe formation
GO:0060540	diaphragm morphogenesis
GO:0060575	intestinal epithelial cell differentiation
GO:0060979	vasculogenesis involved in coronary vascular morphogenesis
GO:0061049	cell growth involved in cardiac muscle cell development
GO:0071333	cellular response to glucose stimulus
GO:0071371	cellular response to gonadotropin stimulus
GO:0071372	cellular response to follicle-stimulating hormone stimulus
GO:0072148	epithelial cell fate commitment
GO:0072520	seminiferous tubule development
GO:0086004	regulation of cardiac muscle cell contraction