InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Slc22a4

Summary

InnateDB Gene

IDBG-172458.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc22a4

Gene Name

solute carrier family 22 (organic cation transporter), member 4

Synonyms

Octn1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020334

Encoded Proteins

IDBP-172460

solute carrier family 22 (organic cation transporter), member 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197208:
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:53983123-54028090

Strand

Reverse strand

Band

B1.3

Transcripts

ENSMUST00000020586	ENSMUSP00000020586
ENSMUST00000146351
ENSMUST00000154369

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015075	ion transmembrane transporter activity
GO:0015226	carnitine transmembrane transporter activity
GO:0015293	symporter activity
GO:0015491	cation:cation antiporter activity
GO:0015651	quaternary ammonium group transmembrane transporter activity
GO:0022857	transmembrane transporter activity
GO:0030165	PDZ domain binding

Biological Process

GO:0006641	triglyceride metabolic process
GO:0006814	sodium ion transport
GO:0009437	carnitine metabolic process
GO:0015697	quaternary ammonium group transport
GO:0015879	carnitine transport
GO:0034220	ion transmembrane transport
GO:0055085	transmembrane transport
GO:1902603	carnitine transmembrane transport