Version 5.4
Homo sapiens Gene: SLC22A4
Summary
InnateDB Gene IDBG-41902.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC22A4
Gene Name solute carrier family 22 (organic cation/ergothioneine transporter), member 4
Synonyms OCTN1
Species Homo sapiens
Ensembl Gene ENSG00000197208
Encoded Proteins
IDBP-41906
solute carrier family 22 (organic cation/ergothioneine transporter), member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:132294443-132344206
Strand Forward strand
Band q31.1
Transcripts
ENST00000200652 ENSP00000200652
ENST00000425923
ENST00000491257
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 1 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008513 secondary active organic cation transmembrane transporter activity
GO:0015075 ion transmembrane transporter activity
GO:0015226 carnitine transmembrane transporter activity
GO:0015293 symporter activity
GO:0015491 cation:cation antiporter activity
GO:0015651 quaternary ammonium group transmembrane transporter activity
GO:0022857 transmembrane transporter activity
GO:0030165 PDZ domain binding
Biological Process
GO:0006641 triglyceride metabolic process
GO:0006814 sodium ion transport
GO:0007589 body fluid secretion
GO:0009437 carnitine metabolic process
GO:0015695 organic cation transport
GO:0015697 quaternary ammonium group transport
GO:0015879 carnitine transport
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
GO:1902603 carnitine transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020334
View Gene Order
ENSBTAG00000031209
Not yet available
Pathways
NETPATH
REACTOME
REACT_22357
Organic cation transport pathway
REACT_19305
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_22345
Organic cation/anion/zwitterion transport pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.310591
RefSeq NM_003059 XM_006714675
HUGO
OMIM
CCDS CCDS4153
HPRD 09171
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca