InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gpx4

Summary

InnateDB Gene

IDBG-172471.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gpx4

Gene Name

glutathione peroxidase 4

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000075706

Encoded Proteins

IDBP-172473

glutathione peroxidase 4

IDBP-271017

glutathione peroxidase 4

IDBP-788072

glutathione peroxidase 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167468:
Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, experimental evidence for alternative splicing exists; alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified. [provided by RefSeq, Jul 2008]
This gene encodes a member of the glutathione peroxidase protein family. Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. The encoded protein has been identified as a moonlighting protein based on its ability to serve dual functions as a peroxidase as well as a structural protein in mature spermatozoa. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:80047166-80056439

Strand

Forward strand

Band

Transcripts

ENSMUST00000097227	ENSMUSP00000094863
ENSMUST00000105372	ENSMUSP00000101011
ENSMUST00000144698
ENSMUST00000145703
ENSMUST00000154095
ENSMUST00000136081
ENSMUST00000183037	ENSMUSP00000138186

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004602	glutathione peroxidase activity
GO:0008430	selenium binding
GO:0043295	glutathione binding
GO:0047066	phospholipid-hydroperoxide glutathione peroxidase activity

Biological Process

GO:0006325	chromatin organization
GO:0006749	glutathione metabolic process
GO:0006979	response to oxidative stress
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0007568	aging
GO:0032355	response to estradiol
GO:0042744	hydrogen peroxide catabolic process
GO:0050727	regulation of inflammatory response
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome