Version 5.4
Mus musculus Gene: Atf6b
Summary
InnateDB Gene IDBG-172578.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Atf6b
Gene Name activating transcription factor 6 beta
Synonyms AA617266; ATF6beta; Creb-rp; Crebl1
Species Mus musculus
Ensembl Gene ENSMUSG00000015461
Encoded Proteins
IDBP-172580
activating transcription factor 6 beta
IDBP-627577
activating transcription factor 6 beta
IDBP-627578
activating transcription factor 6 beta
IDBP-627580
activating transcription factor 6 beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000213676:
The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:34647146-34655074
Strand Forward strand
Band B1
Transcripts
ENSMUST00000015605 ENSMUSP00000015605
ENSMUST00000174614 ENSMUSP00000133786
ENSMUST00000174519 ENSMUSP00000133558
ENSMUST00000173984 ENSMUSP00000133516
ENSMUST00000174156
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006986 response to unfolded protein
GO:0007076 mitotic chromosome condensation
GO:0016458 gene silencing
GO:0045014 negative regulation of transcription by glucose
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0000794 condensed nuclear chromosome
GO:0005622 intracellular
GO:0005730 nucleolus
GO:0005769 early endosome
GO:0005789 endoplasmic reticulum membrane
GO:0005815 microtubule organizing center
GO:0005925 focal adhesion
GO:0012505 endomembrane system
GO:0016021 integral component of membrane
GO:0016363 nuclear matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000213676
View Gene Order
ENSBTAG00000008794
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL G3UXQ6
UniProt Splice Variant
Entrez Gene 12915
UniGene Mm.4068
RefSeq NM_017406 XM_006523572 XM_006523573 XM_006525295 XM_006525296 XM_006536509 XM_006536510 XM_006537242 XM_006537243
OMIM
CCDS CCDS28655
HPRD
IMGT
MGI ID MGI:105121
MGI Symbol Atf6b
EMBL CT009767
GenPept
RNA Seq Atlas 12915

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca