InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atf6b

Summary

InnateDB Protein

IDBP-172580.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atf6b

Protein Name

activating transcription factor 6 beta

Synonyms

AA617266; ATF6beta; Creb-rp; Crebl1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000015605

InnateDB Gene

IDBG-172578 (Atf6b)

Protein Structure

UniProt Annotation

Function

Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.Processed cyclic AMP-dependent transcription factor ATF-6 beta: Nucleus {ECO:0000255PROSITE-ProRule:PRU00978}. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006986	response to unfolded protein
GO:0007076	mitotic chromosome condensation
GO:0016458	gene silencing
GO:0045014	negative regulation of transcription by glucose
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0000794	condensed nuclear chromosome
GO:0005622	intracellular
GO:0005730	nucleolus
GO:0005769	early endosome
GO:0005789	endoplasmic reticulum membrane
GO:0005815	microtubule organizing center
GO:0005925	focal adhesion
GO:0012505	endomembrane system
GO:0016021	integral component of membrane
GO:0016363	nuclear matrix