Version 5.4
Mus musculus Gene: Mapk12
Summary
InnateDB Gene IDBG-172617.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mapk12
Gene Name mitogen-activated protein kinase 12
Synonyms AW123708; Erk6; P38gamma; Prkm12; Sapk3
Species Mus musculus
Ensembl Gene ENSMUSG00000022610
Encoded Proteins
IDBP-172619
mitogen-activated protein kinase 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188130:
Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:89130585-89140703
Strand Reverse strand
Band E3
Transcripts
ENSMUST00000088827 ENSMUSP00000086207
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004707 MAP kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0000165 MAPK cascade
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006950 response to stress
GO:0007049 cell cycle
GO:0018105 peptidyl-serine phosphorylation
GO:0045445 myoblast differentiation
GO:0045786 negative regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000188130
View Gene Order
ENSBTAG00000019574
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_224594
Organelle biogenesis and maintenance pathway
REACT_227951
Signaling by VEGF pathway
REACT_230745
Immune System pathway
REACT_253473
Myogenesis pathway
REACT_243212
DSCAM interactions pathway
REACT_239722
Signalling to RAS pathway
REACT_258600
CDO in myogenesis pathway
REACT_207601
p38MAPK events pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_231290
Signalling to ERKs pathway
REACT_211125
NOD1/2 Signaling Pathway pathway
REACT_248921
Signalling by NGF pathway
REACT_188576
Developmental Biology pathway
REACT_206758
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_188257
Signal Transduction pathway
REACT_211261
Mitochondrial biogenesis pathway
REACT_223082
Cell-Cell communication pathway
REACT_205688
Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway
KEGG
mmu04370
VEGF signaling pathway pathway
mmu04660
T cell receptor signaling pathway pathway
mmu04620
Toll-like receptor signaling pathway pathway
mmu04664
Fc epsilon RI signaling pathway pathway
mmu04912
GnRH signaling pathway pathway
mmu04010
MAPK signaling pathway pathway
mmu04670
Leukocyte transendothelial migration pathway
mmu05014
Amyotrophic lateral sclerosis (ALS) pathway
mmu04722
Neurotrophin signaling pathway pathway
mmu04914
Progesterone-mediated oocyte maturation pathway
mmu04622
RIG-I-like receptor signaling pathway pathway
mmu04621
NOD-like receptor signaling pathway pathway
mmu04114
Oocyte meiosis pathway
mmu05140
Leishmaniasis pathway
mmu04380
Osteoclast differentiation pathway
mmu05145
Toxoplasmosis pathway
mmu05160
Hepatitis C pathway
mmu05142
Chagas disease (American trypanosomiasis) pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
IL-1 signaling pathway pathway
INOH website
Toll-like receptor signaling pathway pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
BMP2 signaling pathway
INOH website
TGF-beta signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_6
KitReceptor pathway
NetPath_24
TSLP pathway
REACTOME
REACT_75776
NOD1/2 Signaling Pathway pathway
REACT_12065
p38MAPK events pathway
REACT_12033
Signalling to RAS pathway
REACT_25299
DSCAM interactions pathway
REACT_21402
CDO in myogenesis pathway
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_111155
Cell-Cell communication pathway
REACT_200686
Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway
REACT_12529
Signaling by VEGF pathway
REACT_200788
Mitochondrial biogenesis pathway
REACT_6802
Innate Immune System pathway
REACT_111102
Signal Transduction pathway
REACT_21303
Myogenesis pathway
REACT_75913
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
REACT_6900
Immune System pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_12058
Signalling to ERKs pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
KEGG
hsa04912
GnRH signaling pathway pathway
hsa04370
VEGF signaling pathway pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa04010
MAPK signaling pathway pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa05014
Amyotrophic lateral sclerosis (ALS) pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa04622
RIG-I-like receptor signaling pathway pathway
hsa04621
NOD-like receptor signaling pathway pathway
hsa04114
Oocyte meiosis pathway
hsa05140
Leishmaniasis pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa04380
Osteoclast differentiation pathway
hsa05131
Shigellosis pathway
hsa05145
Toxoplasmosis pathway
hsa05160
Hepatitis C pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
IL-1 signaling pathway pathway
INOH website
Toll-like receptor signaling pathway pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
TGF-beta signaling pathway
INOH website
BMP2 signaling pathway
PID NCI
p38gammadeltapathway
Signaling mediated by p38-gamma and p38-delta
rhoa_pathway
RhoA signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_013871 XM_006521063
OMIM
CCDS CCDS27740
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca