Version 5.4
Homo sapiens Gene: MFAP5
Summary
InnateDB Gene IDBG-17287.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MFAP5
Gene Name microfibrillar associated protein 5
Synonyms MAGP-2; MAGP2; MFAP-5; MP25
Species Homo sapiens
Ensembl Gene ENSG00000197614
Encoded Proteins
IDBP-17289
microfibrillar associated protein 5
IDBP-237270
microfibrillar associated protein 5
IDBP-366084
microfibrillar associated protein 5
IDBP-591595
microfibrillar associated protein 5
IDBP-588194
microfibrillar associated protein 5
IDBP-588157
microfibrillar associated protein 5
IDBP-599582
microfibrillar associated protein 5
IDBP-596782
microfibrillar associated protein 5
IDBP-594277
microfibrillar associated protein 5
IDBP-594858
microfibrillar associated protein 5
IDBP-602162
microfibrillar associated protein 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a 25-kD microfibril-associated glycoprotein which is rich in serine and threonine residues. It lacks a hydrophobic carboxyl terminus and proline-, glutamine-, and tyrosine-rich regions, which are characteristics of a related 31-kDa microfibril-associated glycoprotein (MFAP2). The close similarity between these two proteins is confined to a central region of 60 aa where precise alignment of 7 cysteine residues occurs. The structural differences suggest that this encoded protein has some functions that are distinct from those of MFAP2. [provided by RefSeq, Jul 2008]
This gene encodes a 25-kD microfibril-associated glycoprotein which is a component of microfibrils of the extracellular matrix. The encoded protein promotes attachment of cells to microfibrils via alpha-V-beta-3 integrin. Deficiency of this gene in mice results in neutropenia. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:8637346-8662888
Strand Reverse strand
Band p13.31
Transcripts
ENST00000359478 ENSP00000352455
ENST00000396549 ENSP00000379798
ENST00000433590 ENSP00000411997
ENST00000535411 ENSP00000441185
ENST00000543467 ENSP00000444531
ENST00000543369 ENSP00000441492
ENST00000544211 ENSP00000443839
ENST00000535336 ENSP00000438525
ENST00000538694
ENST00000537009 ENSP00000439289
ENST00000534833
ENST00000544889 ENSP00000445799
ENST00000538107
ENST00000537128
ENST00000540087 ENSP00000440496
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005201 extracellular matrix structural constituent
Biological Process
GO:0030198 extracellular matrix organization
GO:0043206 extracellular fibril organization
Cellular Component
GO:0001527 microfibril
GO:0005576 extracellular region
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030116
View Gene Order
ENSBTAG00000000310
Not yet available
Pathways
NETPATH
REACTOME
REACT_150331
Molecules associated with elastic fibres pathway
REACT_150366
Elastic fibre formation pathway
REACT_118779
Extracellular matrix organization pathway
KEGG
INOH
PID NCI
notch_pathway
Notch signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.512842
RefSeq NM_003480 XM_006719154
HUGO
OMIM
CCDS CCDS73437 CCDS8595
HPRD 03063
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca