Version 5.4
| Bos taurus Gene: MFAP5 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||
| InnateDB Gene | IDBG-639756.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | MFAP5 | ||||||||
| Gene Name | Microfibrillar-associated protein 5 | ||||||||
| Synonyms | MAGP2 | ||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000000310 | ||||||||
| Encoded Proteins |
microfibrillar-associated protein 5 precursor
|
||||||||
| Protein Structure |
|
||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197614:
This gene encodes a 25-kD microfibril-associated glycoprotein which is rich in serine and threonine residues. It lacks a hydrophobic carboxyl terminus and proline-, glutamine-, and tyrosine-rich regions, which are characteristics of a related 31-kDa microfibril-associated glycoprotein (MFAP2). The close similarity between these two proteins is confined to a central region of 60 aa where precise alignment of 7 cysteine residues occurs. The structural differences suggest that this encoded protein has some functions that are distinct from those of MFAP2. [provided by RefSeq, Jul 2008] This gene encodes a 25-kD microfibril-associated glycoprotein which is a component of microfibrils of the extracellular matrix. The encoded protein promotes attachment of cells to microfibrils via alpha-V-beta-3 integrin. Deficiency of this gene in mice results in neutropenia. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014] |
||||||||
| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 5:101647629-101659377 | ||||||||
| Strand | Forward strand | ||||||||
| Band | |||||||||
| Transcripts |
|
||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
|
||||||||
| Gene Ontology | |||||||||
Molecular Function |
|
||||||||
| Biological Process |
|
||||||||
| Cellular Component |
|
||||||||
| Orthologs | |||||||||
|
Species
Homo sapiens
Mus musculus
|
Gene ID
Gene Order
|
||||||||
| Pathways | |||||||||
| NETPATH | |||||||||
| REACTOME |
Extracellular matrix organization pathway
Molecules associated with elastic fibres pathway
Elastic fibre formation pathway
|
||||||||
| KEGG | |||||||||
| INOH | |||||||||
| PID NCI | |||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME |
Molecules associated with elastic fibres pathway
Elastic fibre formation pathway
Extracellular matrix organization pathway
Elastic fibre formation pathway
Molecules associated with elastic fibres pathway
Extracellular matrix organization pathway
|
||||||||
| KEGG | |||||||||
| INOH | |||||||||
| PID NCI |
Notch signaling pathway
|
||||||||
| Cross-References | |||||||||
| SwissProt | Q28022 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 281908 | ||||||||
| UniGene | Bt.2560 | ||||||||
| RefSeq | NM_174386 XM_005207047 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | BC102769 U37282 | ||||||||
| GenPept | AAA96751 AAI02770 | ||||||||
| RNA Seq Atlas | 281908 | ||||||||