InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Serpine2

Summary

InnateDB Gene

IDBG-173051.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Serpine2

Gene Name

serine (or cysteine) peptidase inhibitor, clade E, member 2

Synonyms

B230326M24Rik; PAI-1; PI-7; PI7; PN-1; Spi4

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026249

Encoded Proteins

IDBP-173053

serine (or cysteine) peptidase inhibitor, clade E, member 2

IDBP-789872

serine (or cysteine) peptidase inhibitor, clade E, member 2

IDBP-789873

serine (or cysteine) peptidase inhibitor, clade E, member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135919:
This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:79794197-79861180

Strand

Reverse strand

Band

Transcripts

ENSMUST00000027467	ENSMUSP00000027467
ENSMUST00000153862
ENSMUST00000189793	ENSMUSP00000140065
ENSMUST00000190724	ENSMUSP00000140255
ENSMUST00000191529
ENSMUST00000191026

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0005539	glycosaminoglycan binding
GO:0008201	heparin binding

Biological Process

GO:0007596	blood coagulation
GO:0008285	negative regulation of cell proliferation
GO:0009611	response to wounding
GO:0010466	negative regulation of peptidase activity
GO:0010544	negative regulation of platelet activation
GO:0010757	negative regulation of plasminogen activation
GO:0010766	negative regulation of sodium ion transport
GO:0010951	negative regulation of endopeptidase activity
GO:0010955	negative regulation of protein processing
GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling
GO:0021683	cerebellar granular layer morphogenesis
GO:0030195	negative regulation of blood coagulation
GO:0030308	negative regulation of cell growth
GO:0032940	secretion by cell
GO:0033363	secretory granule organization
GO:0042177	negative regulation of protein catabolic process
GO:0042628	mating plug formation
GO:0045861	negative regulation of proteolysis
GO:0045879	negative regulation of smoothened signaling pathway
GO:0048505	regulation of timing of cell differentiation
GO:0048711	positive regulation of astrocyte differentiation
GO:0050974	detection of mechanical stimulus involved in sensory perception
GO:0051966	regulation of synaptic transmission, glutamatergic
GO:0060291	long-term synaptic potentiation
GO:0060384	innervation
GO:0061108	seminal vesicle epithelium development
GO:0090331	negative regulation of platelet aggregation

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005829	cytosol
GO:0031012	extracellular matrix
GO:0031091	platelet alpha granule
GO:0031232	extrinsic component of external side of plasma membrane
GO:0031594	neuromuscular junction