Version 5.4
Homo sapiens Gene: SERPINE2
Summary
InnateDB Gene IDBG-82303.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERPINE2
Gene Name serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
Synonyms GDN; GDNPF; PI-7; PI7; PN-1; PN1; PNI
Species Homo sapiens
Ensembl Gene ENSG00000135919
Encoded Proteins
IDBP-82305
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
IDBP-292980
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
IDBP-292979
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
IDBP-389139
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
IDBP-389142
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
IDBP-389143
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
IDBP-389144
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:223975112-224039319
Strand Reverse strand
Band q36.1
Transcripts
ENST00000258405 ENSP00000258405
ENST00000409304 ENSP00000386412
ENST00000409840 ENSP00000386969
ENST00000447280 ENSP00000415786
ENST00000432738 ENSP00000408452
ENST00000454956 ENSP00000399655
ENST00000423446 ENSP00000394518
ENST00000473202
ENST00000478966
ENST00000489065
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0005539 glycosaminoglycan binding
GO:0008201 heparin binding
Biological Process
GO:0007596 blood coagulation
GO:0008285 negative regulation of cell proliferation
GO:0009611 response to wounding
GO:0010466 negative regulation of peptidase activity
GO:0010544 negative regulation of platelet activation
GO:0010757 negative regulation of plasminogen activation
GO:0010766 negative regulation of sodium ion transport
GO:0010951 negative regulation of endopeptidase activity
GO:0010955 negative regulation of protein processing
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
GO:0021683 cerebellar granular layer morphogenesis
GO:0030195 negative regulation of blood coagulation
GO:0030308 negative regulation of cell growth
GO:0030334 regulation of cell migration
GO:0032940 secretion by cell
GO:0033363 secretory granule organization
GO:0042177 negative regulation of protein catabolic process
GO:0042628 mating plug formation
GO:0045861 negative regulation of proteolysis
GO:0045879 negative regulation of smoothened signaling pathway
GO:0048505 regulation of timing of cell differentiation
GO:0048711 positive regulation of astrocyte differentiation
GO:0050974 detection of mechanical stimulus involved in sensory perception
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0060291 long-term synaptic potentiation
GO:0060384 innervation
GO:0061108 seminal vesicle epithelium development
GO:0090331 negative regulation of platelet aggregation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0031012 extracellular matrix
GO:0031091 platelet alpha granule
GO:0031232 extrinsic component of external side of plasma membrane
GO:0031594 neuromuscular junction
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026249
View Gene Order
ENSBTAG00000008717
Not yet available
Pathways
NETPATH
REACTOME
REACT_641
Dissolution of Fibrin Clot pathway
REACT_326
Intrinsic Pathway pathway
REACT_1439
Common Pathway pathway
REACT_2051
Formation of Fibrin Clot (Clotting Cascade) pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P07093
TrEMBL A0A024R451 C9JN98 C9JRK5 C9K031
UniProt Splice Variant
Entrez Gene 5270
UniGene Hs.38449 Hs.708453 Hs.727245
RefSeq NM_006216 XM_005246642 NM_001136528 NM_001136530
HUGO HGNC:8951
OMIM 177010
CCDS CCDS2460 CCDS46525 CCDS46526
HPRD 01510
IMGT
EMBL AC073641 AK295564 AK312499 BC015663 BC042628 CH471063 M17783
GenPept AAA35883 AAH15663 AAH42628 AAY14926 BAG35401 BAG58464 EAW70821 EAW70822 EAW70823
RNA Seq Atlas 5270

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca