Version 5.4
Mus musculus Gene: Dmgdh
Summary
InnateDB Gene IDBG-173068.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dmgdh
Gene Name dimethylglycine dehydrogenase precursor
Synonyms 1200014D15Rik; AI787269
Species Mus musculus
Ensembl Gene ENSMUSG00000042102
Encoded Proteins
IDBP-173070
dimethylglycine dehydrogenase precursor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:93674433-93752831
Strand Forward strand
Band C3
Transcripts
ENSMUST00000048001 ENSMUSP00000039663
ENSMUST00000126196
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004047 aminomethyltransferase activity
GO:0016491 oxidoreductase activity
GO:0044822 poly(A) RNA binding
GO:0047865 dimethylglycine dehydrogenase activity
Biological Process
GO:0006544 glycine metabolic process
GO:0006546 glycine catabolic process
GO:0006579 amino-acid betaine catabolic process
GO:0032259 methylation
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000132837
View Gene Order
ENSBTAG00000002110
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00260
Glycine, serine and threonine metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00260
Glycine, serine and threonine metabolism pathway
INOH
INOH website
Glycine Serine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.21789
RefSeq NM_028772
OMIM
CCDS CCDS26690
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca