InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cyp17a1

Summary

InnateDB Gene

IDBG-173457.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyp17a1

Gene Name

cytochrome P450, family 17, subfamily a, polypeptide 1

Synonyms

Cyp17; p450c17

Species

Mus musculus

Ensembl Gene

ENSMUSG00000003555

Encoded Proteins

IDBP-173459

cytochrome P450, family 17, subfamily a, polypeptide 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148795:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:46667165-46672974

Strand

Reverse strand

Band

Transcripts

ENSMUST00000026012	ENSMUSP00000026012
ENSMUST00000131142
ENSMUST00000156577

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004508	steroid 17-alpha-monooxygenase activity
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0047442	17-alpha-hydroxyprogesterone aldolase activity

Biological Process

GO:0006082	organic acid metabolic process
GO:0006694	steroid biosynthetic process
GO:0006704	glucocorticoid biosynthetic process
GO:0008202	steroid metabolic process
GO:0008584	male gonad development
GO:0009635	response to herbicide
GO:0009636	response to toxic substance
GO:0010033	response to organic substance
GO:0010034	response to acetate
GO:0010212	response to ionizing radiation
GO:0014070	response to organic cyclic compound
GO:0017085	response to insecticide
GO:0018879	biphenyl metabolic process
GO:0018894	dibenzo-p-dioxin metabolic process
GO:0018958	phenol-containing compound metabolic process
GO:0018963	phthalate metabolic process
GO:0021766	hippocampus development
GO:0030325	adrenal gland development
GO:0030728	ovulation
GO:0031667	response to nutrient levels
GO:0032526	response to retinoic acid
GO:0033327	Leydig cell differentiation
GO:0034097	response to cytokine
GO:0034698	response to gonadotropin
GO:0042446	hormone biosynthetic process
GO:0042448	progesterone metabolic process
GO:0042493	response to drug
GO:0048545	response to steroid hormone
GO:0051591	response to cAMP
GO:0051597	response to methylmercury
GO:0055114	oxidation-reduction process
GO:0060992	response to fungicide
GO:0071222	cellular response to lipopolysaccharide
GO:0071236	cellular response to antibiotic
GO:0071371	cellular response to gonadotropin stimulus
GO:0090031	positive regulation of steroid hormone biosynthetic process

Cellular Component

GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0016020	membrane
GO:0030424	axon
GO:0042995	cell projection
GO:0043025	neuronal cell body
GO:0043231	intracellular membrane-bounded organelle