InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.65130

Summary

InnateDB Gene

IDBG-639257.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.65130

Gene Name

steroid 17-alpha-hydroxylase/17,20 lyase precursor

Synonyms

CYP17; CYPXVII; P450-C17; P450c17

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014335

Encoded Proteins

IDBP-691399

steroid 17-alpha-hydroxylase/17,20 lyase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148795:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 26:23694362-23700404

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000019061

ENSBTAP00000019061

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0004508	steroid 17-alpha-monooxygenase activity
GO:0005506	iron ion binding
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0046872	metal ion binding

Biological Process

GO:0006704	glucocorticoid biosynthetic process
GO:0008202	steroid metabolic process
GO:0042446	hormone biosynthetic process
GO:0042448	progesterone metabolic process
GO:0055114	oxidation-reduction process