InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cyp21a1

Summary

InnateDB Gene

IDBG-173549.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyp21a1

Gene Name

cytochrome P450, family 21, subfamily a, polypeptide 1

Synonyms

21-OH; 21OH; 21OHA; 21OHB; Cyp21; Cyp21-ps1; Cyp21a2-ps; Cyp21a2ps; Cyp21B; CYP21OH-A; Oh21-1; Oh21-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024365

Encoded Proteins

IDBP-173551

cytochrome P450, family 21, subfamily a, polypeptide 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000231852:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in this gene cause congenital adrenal hyperplasia. A related pseudogene is located near this gene; gene conversion events involving the functional gene and the pseudogene are thought to account for many cases of steroid 21-hydroxylase deficiency. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:34801348-34804561

Strand

Reverse strand

Band

Transcripts

ENSMUST00000025223	ENSMUSP00000025223
ENSMUST00000173970
ENSMUST00000173394

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004509	steroid 21-monooxygenase activity
GO:0005496	steroid binding
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding