Version 5.4
Mus musculus Protein: Cyp21a1
Summary
InnateDB Protein IDBP-173551.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cyp21a1
Protein Name cytochrome P450, family 21, subfamily a, polypeptide 1
Synonyms 21-OH; 21OH; 21OHA; 21OHB; Cyp21; Cyp21-ps1; Cyp21a2-ps; Cyp21a2ps; Cyp21B; CYP21OH-A; Oh21-1; Oh21-2;
Species Mus musculus
Ensembl Protein ENSMUSP00000025223
InnateDB Gene IDBG-173549 (Cyp21a1)
Protein Structure
UniProt Annotation
Function Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.
Subcellular Localization Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004509 steroid 21-monooxygenase activity
GO:0005496 steroid binding
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
Biological Process
GO:0006694 steroid biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
Protein Structure and Domains
PDB ID MGI:88591
InterPro IPR001128 Cytochrome P450
IPR002397 Cytochrome P450, B-class
IPR002401 Cytochrome P450, E-class, group I
IPR002403 Cytochrome P450, E-class, group IV
PFAM PF00067
PRINTS PR00385
PR00359
PR00463
PR00465
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P03940
PhosphoSite PhosphoSite-P03940
TrEMBL Q62239
UniProt Splice Variant
Entrez Gene 13079
UniGene Mm.440407
RefSeq NP_034125
MGI ID
MGI Symbol Cyp21a1
OMIM
CCDS CCDS28658
HPRD
IMGT
EMBL AB015623 AF049850 BC127167 M15009 M64933 M73820
GenPept AAA37114 AAA40116 AAA40118 AAC05278 AAI27168 BAA31153

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca