Version 5.4
Mus musculus Gene: Cct8
Summary
InnateDB Gene IDBG-173563.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cct8
Gene Name chaperonin containing Tcp1, subunit 8 (theta)
Synonyms AI132397; Cctq; Tcpq
Species Mus musculus
Ensembl Gene ENSMUSG00000025613
Encoded Proteins
IDBP-173565
chaperonin containing Tcp1, subunit 8 (theta)
IDBP-707406
IDBP-706886
IDBP-707303
IDBP-707031
IDBP-707373
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156261:
This gene encodes the theta subunit of the CCT chaperonin, which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of newly synthesized proteins. Alternative splicing results in multiple transcript variants of this gene. A pseudogene related to this gene is located on chromosome 1. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:87483326-87495873
Strand Reverse strand
Band C3.3
Transcripts
ENSMUST00000026704 ENSMUSP00000026704
ENSMUST00000176589
ENSMUST00000177376 ENSMUSP00000135498
ENSMUST00000175750 ENSMUSP00000134920
ENSMUST00000176041 ENSMUSP00000135377
ENSMUST00000176750 ENSMUSP00000135830
ENSMUST00000175977 ENSMUSP00000135651
ENSMUST00000177485
ENSMUST00000177301
ENSMUST00000176241
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 84 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 84 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0051082 unfolded protein binding
Biological Process
GO:0006457 protein folding
GO:0007339 binding of sperm to zona pellucida
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0002199 zona pellucida receptor complex
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005832 chaperonin-containing T-complex
GO:0005874 microtubule
GO:0016235 aggresome
GO:0044297 cell body
GO:0045111 intermediate filament cytoskeleton
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000156261
View Gene Order
ENSBTAG00000014233
Not yet available
Pathways
NETPATH
REACTOME
REACT_258900
Chaperonin-mediated protein folding pathway
REACT_244970
Association of TriC/CCT with target proteins during biosynthesis pathway
REACT_252491
Folding of actin by CCT/TriC pathway
REACT_247926
Metabolism of proteins pathway
REACT_260833
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
REACT_245534
Protein folding pathway
REACT_258053
Formation of tubulin folding intermediates by CCT/TriC pathway
REACT_245663
Prefoldin mediated transfer of substrate to CCT/TriC pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_11
TCR pathway
REACTOME
REACT_16907
Association of TriC/CCT with target proteins during biosynthesis pathway
REACT_17050
Folding of actin by CCT/TriC pathway
REACT_16936
Prefoldin mediated transfer of substrate to CCT/TriC pathway
REACT_16956
Formation of tubulin folding intermediates by CCT/TriC pathway
REACT_16952
Protein folding pathway
REACT_17004
Chaperonin-mediated protein folding pathway
REACT_17015
Metabolism of proteins pathway
REACT_17029
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
REACT_223239
Prefoldin mediated transfer of substrate to CCT/TriC pathway
REACT_225808
Folding of actin by CCT/TriC pathway
REACT_203284
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
REACT_219091
Chaperonin-mediated protein folding pathway
REACT_213782
Metabolism of proteins pathway
REACT_215927
Protein folding pathway
REACT_203091
Association of TriC/CCT with target proteins during biosynthesis pathway
REACT_214148
Formation of tubulin folding intermediates by CCT/TriC pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL H3BKR8
UniProt Splice Variant
Entrez Gene 12469
UniGene Mm.328673
RefSeq NM_009840
OMIM
CCDS CCDS37384
HPRD
IMGT
MGI ID MGI:107183
MGI Symbol Cct8
EMBL AC154631
GenPept
RNA Seq Atlas 12469

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca