Version 5.4
Mus musculus Gene: Ppat
Summary
InnateDB Gene IDBG-173592.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppat
Gene Name phosphoribosyl pyrophosphate amidotransferase
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000029246
Encoded Proteins
IDBP-533795
phosphoribosyl pyrophosphate amidotransferase
IDBP-538126
phosphoribosyl pyrophosphate amidotransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128059:
The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and seven of this pathway, are located in close proximity on chromosome 4, and divergently transcribed from an intergenic region. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:76913249-76951578
Strand Reverse strand
Band C3.3
Transcripts
ENSMUST00000031158
ENSMUST00000155272 ENSMUSP00000116438
ENSMUST00000140076 ENSMUSP00000120632
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004044 amidophosphoribosyltransferase activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0001822 kidney development
GO:0006189 'de novo' IMP biosynthetic process
GO:0006543 glutamine catabolic process
GO:0007595 lactation
GO:0008152 metabolic process
GO:0009113 purine nucleobase biosynthetic process
GO:0009116 nucleoside metabolic process
GO:0009168 purine ribonucleoside monophosphate biosynthetic process
GO:0019693 ribose phosphate metabolic process
GO:0031100 organ regeneration
GO:0032869 cellular response to insulin stimulus
GO:0035690 cellular response to drug
GO:0042493 response to drug
GO:0051289 protein homotetramerization
GO:0060135 maternal process involved in female pregnancy
Cellular Component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000128059
View Gene Order
ENSBTAG00000010571
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00230
Purine metabolism pathway
mmu00250
Alanine, aspartate and glutamate metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1776
Purine ribonucleoside monophosphate biosynthesis pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_522
Purine metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00230
Purine metabolism pathway
hsa00250
Alanine, aspartate and glutamate metabolism pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL Q3TKC5 Q3UGA8 Q8CIH9
UniProt Splice Variant
Entrez Gene 231327
UniGene Mm.202337
RefSeq NM_172146
OMIM
CCDS CCDS51527
HPRD
IMGT
MGI ID MGI:2387203
MGI Symbol Ppat
EMBL AC114666 AK148034 AK164506 AK167057 BC023841 CH466524
GenPept AAH23841 BAE28301 BAE37815 BAE39220 EDL37915
RNA Seq Atlas 231327

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca