Version 5.4
Mus musculus Protein: Ppat
Summary
InnateDB Protein IDBP-538126.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppat
Protein Name phosphoribosyl pyrophosphate amidotransferase
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000120632
InnateDB Gene IDBG-173592 (Ppat)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004044 amidophosphoribosyltransferase activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0001822 kidney development
GO:0006189 'de novo' IMP biosynthetic process
GO:0006543 glutamine catabolic process
GO:0007595 lactation
GO:0008152 metabolic process
GO:0009113 purine nucleobase biosynthetic process
GO:0009116 nucleoside metabolic process
GO:0009168 purine ribonucleoside monophosphate biosynthetic process
GO:0019693 ribose phosphate metabolic process
GO:0031100 organ regeneration
GO:0032869 cellular response to insulin stimulus
GO:0035690 cellular response to drug
GO:0042493 response to drug
GO:0051289 protein homotetramerization
GO:0060135 maternal process involved in female pregnancy
Cellular Component
Protein Structure and Domains
PDB ID MGI:2387203
InterPro IPR000583 Class II glutamine amidotransferase domain
IPR000836 Phosphoribosyltransferase domain
IPR005854 Amidophosphoribosyl transferase
IPR029055 Nucleophile aminohydrolases, N-terminal
IPR029057 Phosphoribosyltransferase-like
PFAM PF00310
PF13537
PF00156
PRINTS
PIRSF PIRSF000485
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-Q3TKC5
TrEMBL Q8CIH9
UniProt Splice Variant
Entrez Gene 231327
UniGene Mm.202337
RefSeq NP_742158
MGI ID
MGI Symbol Ppat
OMIM
CCDS CCDS51527
HPRD
IMGT
EMBL AC114666 AK148034 AK164506 AK167057 BC023841 CH466524
GenPept AAH23841 BAE28301 BAE37815 BAE39220 EDL37915

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca