Version 5.4
Mus musculus Gene: Txndc12
Summary
InnateDB Gene IDBG-173761.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Txndc12
Gene Name thioredoxin domain containing 12 (endoplasmic reticulum)
Synonyms 0610040B21Rik; ERp16; ERp19
Species Mus musculus
Ensembl Gene ENSMUSG00000028567
Encoded Proteins
IDBP-173763
thioredoxin domain containing 12 (endoplasmic reticulum)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117862:
This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:108834601-108862127
Strand Forward strand
Band C7
Transcripts
ENSMUST00000030296 ENSMUSP00000030296
ENSMUST00000147581
ENSMUST00000154017
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0019153 protein-disulfide reductase (glutathione) activity
Biological Process
GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005788 endoplasmic reticulum lumen
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000117862
View Gene Order
ENSBTAG00000011024
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00480
Glutathione metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00480
Glutathione metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.159965 Mm.468934
RefSeq NM_025334
OMIM
CCDS CCDS18457
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca