Version 5.4
Mus musculus Protein: Txndc12
Summary
InnateDB Protein IDBP-173763.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Txndc12
Protein Name thioredoxin domain containing 12 (endoplasmic reticulum)
Synonyms 0610040B21Rik; ERp16; ERp19;
Species Mus musculus
Ensembl Protein ENSMUSP00000030296
InnateDB Gene IDBG-173761 (Txndc12)
Protein Structure
UniProt Annotation
Function Possesses significant protein thiol-disulfide oxidase activity. {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum lumen {ECO:0000255PROSITE-ProRule:PRU10138, ECO:0000269PubMed:12930873}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0019153 protein-disulfide reductase (glutathione) activity
Biological Process
GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005788 endoplasmic reticulum lumen
Protein Structure and Domains
PDB ID MGI:1913323
InterPro IPR012336 Thioredoxin-like fold
IPR013766 Thioredoxin domain
PFAM PF13098
PF13192
PF13462
PF13905
PF00085
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CQU0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 66073
UniGene Mm.468934
RefSeq NP_079610
MGI ID
MGI Symbol Txndc12
OMIM
CCDS CCDS18457
HPRD
IMGT
EMBL AK002862 AK003481 AY548113 BC006857
GenPept AAH06857 AAS55653 BAB22413 BAB22811

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca