InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hopx

Summary

InnateDB Gene

IDBG-173899.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hopx

Gene Name

HOP homeobox

Synonyms

1110018K11Rik; 1200015P04Rik; 2300002F06Rik; AI848177; AW490897; Cameo; Hdop; Hod; Hop; Ob1; Obl; Toto

Species

Mus musculus

Ensembl Gene

ENSMUSG00000059325

Encoded Proteins

IDBP-173901

HOP homeobox

IDBP-253850

HOP homeobox

IDBP-400760

HOP homeobox

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171476:
The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:77086988-77115121

Strand

Reverse strand

Band

C3.3

Transcripts

ENSMUST00000081964	ENSMUSP00000080630
ENSMUST00000113453	ENSMUSP00000109080
ENSMUST00000120827	ENSMUSP00000113295

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001829	trophectodermal cell differentiation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007507	heart development
GO:0008016	regulation of heart contraction
GO:0016575	histone deacetylation
GO:0043393	regulation of protein binding
GO:0043415	positive regulation of skeletal muscle tissue regeneration
GO:0045596	negative regulation of cell differentiation
GO:0048286	lung alveolus development
GO:0051155	positive regulation of striated muscle cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000171476

View Gene Order

ENSBTAG00000002333

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.467479 Mm.478741

RefSeq

NM_001159900 NM_001159901 NM_175606

OMIM

CCDS

CCDS39120

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas