InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hopx

Summary

InnateDB Protein

IDBP-253850.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hopx

Protein Name

HOP homeobox

Synonyms

1110018K11Rik; 1200015P04Rik; 2300002F06Rik; AI848177; AW490897; Cameo; Hdop; Hod; Hop; Ob1; Obl; Toto;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109080

InnateDB Gene

IDBG-173899 (Hopx)

Protein Structure

UniProt Annotation

Function

Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. {ECO:0000269PubMed:12297045, ECO:0000269PubMed:12297046}.

Subcellular Localization

Nucleus. Cytoplasm. Note=According to PubMed:14516659 it is cytoplasmic.

Disease Associations

Tissue Specificity

Expressed in the embryonic and adult heart and in the adult brain, liver, lung, skeletal muscle, intestine and spleen. Throughout embryonic and postnatal development, it is expressed in the myocardium. {ECO:0000269PubMed:12297045, ECO:0000269PubMed:12297046, ECO:0000269PubMed:14516659}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001829	trophectodermal cell differentiation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007507	heart development
GO:0008016	regulation of heart contraction
GO:0016575	histone deacetylation
GO:0043393	regulation of protein binding
GO:0043415	positive regulation of skeletal muscle tissue regeneration
GO:0045596	negative regulation of cell differentiation
GO:0048286	lung alveolus development
GO:0051155	positive regulation of striated muscle cell differentiation