Version 5.4
Mus musculus Gene: Spink2
Summary
InnateDB Gene IDBG-173938.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spink2
Gene Name serine peptidase inhibitor, Kazal type 2
Synonyms 1700007F22Rik; AV038945; HUSI-II
Species Mus musculus
Ensembl Gene ENSMUSG00000053030
Encoded Proteins
IDBP-173940
serine peptidase inhibitor, Kazal type 2
IDBP-400755
serine peptidase inhibitor, Kazal type 2
IDBP-400752
serine peptidase inhibitor, Kazal type 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128040:
This gene encodes a member of the family of serine protease inhibitors of the Kazal type (SPINK). The encoded protein acts as a trypsin and acrosin inhibitor in the genital tract and is localized in the spermatozoa. The protein has been associated with the progression of lymphomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:77205107-77211471
Strand Reverse strand
Band C3.3
Transcripts
ENSMUST00000065216 ENSMUSP00000067117
ENSMUST00000121825 ENSMUSP00000113823
ENSMUST00000120429 ENSMUSP00000112806
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0002176 male germ cell proliferation
GO:0006915 apoptotic process
GO:0007283 spermatogenesis
GO:0007286 spermatid development
GO:0008584 male gonad development
GO:0009566 fertilization
GO:0072520 seminiferous tubule development
GO:1900004 negative regulation of serine-type endopeptidase activity
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005576 extracellular region
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000128040
View Gene Order
Cross-References
SwissProt Q8BMY7
TrEMBL D3YTY0 D3Z3X9
UniProt Splice Variant
Entrez Gene 69982
UniGene Mm.46106
RefSeq NM_001289764 NM_001289767 NM_001289768 NM_183284
OMIM
CCDS CCDS39121
HPRD
IMGT
MGI ID MGI:1917232
MGI Symbol Spink2
EMBL AC165975 AK005709 BC087876
GenPept AAH87876 BAC25122
RNA Seq Atlas 69982

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca