InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Spink2

Summary

InnateDB Protein

IDBP-173940.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spink2

Protein Name

serine peptidase inhibitor, Kazal type 2

Synonyms

1700007F22Rik; AV038945; HUSI-II;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000067117

InnateDB Gene

IDBG-173938 (Spink2)

Protein Structure

UniProt Annotation

Function

Inhibits trypsin in a dose-dependent manner. Required for maintenance of normal spermatogenesis. May be involved in regulating serine protease-dependent germ cell apoptosis. {ECO:0000269PubMed:21705336}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in sperm (at protein level). Expressed in testis but not in ovary, brain, heart, kidney or lung. Within testis, expressed in epididymis and germ cells. {ECO:0000269PubMed:21705336, ECO:0000269Ref.3}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding

Biological Process

GO:0002176	male germ cell proliferation
GO:0006915	apoptotic process
GO:0007283	spermatogenesis
GO:0007286	spermatid development
GO:0008584	male gonad development
GO:0009566	fertilization
GO:0072520	seminiferous tubule development
GO:1900004	negative regulation of serine-type endopeptidase activity