InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mbd3

Summary

InnateDB Gene

IDBG-174078.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mbd3

Gene Name

methyl-CpG binding domain protein 3

Synonyms

AI181826; AU019209

Species

Mus musculus

Ensembl Gene

ENSMUSG00000035478

Encoded Proteins

IDBP-174080

methyl-CpG binding domain protein 3

IDBP-271065

methyl-CpG binding domain protein 3

IDBP-271067

methyl-CpG binding domain protein 3

IDBP-271069

methyl-CpG binding domain protein 3

IDBP-535297

methyl-CpG binding domain protein 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000071655:
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA. The predicted MBD3 protein shares 71% and 94% identity with MBD2 (isoform 1) and mouse Mbd3. MBD3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:80392539-80399550

Strand

Reverse strand

Band

Transcripts

ENSMUST00000092295	ENSMUSP00000089948
ENSMUST00000105349	ENSMUSP00000100986
ENSMUST00000105348	ENSMUSP00000100985
ENSMUST00000105347	ENSMUSP00000100984
ENSMUST00000142997	ENSMUSP00000120675
ENSMUST00000125618

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	50 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0008327	methyl-CpG binding
GO:0031492	nucleosomal DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0006346	methylation-dependent chromatin silencing
GO:0006351	transcription, DNA-templated
GO:0009888	tissue development
GO:0016573	histone acetylation
GO:0043044	ATP-dependent chromatin remodeling

Cellular Component

GO:0000785	chromatin
GO:0000790	nuclear chromatin
GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016581	NuRD complex
GO:0043234	protein complex