Version 5.4
Mus musculus Gene: Inf2
Summary
InnateDB Gene IDBG-174407.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Inf2
Gene Name inverted formin, FH2 and WH2 domain containing
Synonyms 2610204M08Rik; AA589465; AW125550; EG629699
Species Mus musculus
Ensembl Gene ENSMUSG00000037679
Encoded Proteins
IDBP-174411
inverted formin, FH2 and WH2 domain containing
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000203485:
This gene represents a member of the formin family of proteins. It is considered a diaphanous formin due to the presence of a diaphanous inhibitory domain located at the N-terminus of the encoded protein. Studies of a similar mouse protein indicate that the protein encoded by this locus may function in polymerization and depolymerization of actin filaments. Mutations at this locus have been associated with focal segmental glomerulosclerosis 5.[provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:112588784-112615556
Strand Forward strand
Band F1
Transcripts
ENSMUST00000101029 ENSMUSP00000098591
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005488 binding
GO:0017048 Rho GTPase binding
Biological Process
GO:0016043 cellular component organization
GO:0030036 actin cytoskeleton organization
GO:0032535 regulation of cellular component size
GO:0090140 regulation of mitochondrial fission
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000203485
View Gene Order
ENSBTAG00000007187
Not yet available
Cross-References
SwissProt
TrEMBL E9QLA5
UniProt Splice Variant
Entrez Gene 70435
UniGene Mm.250193
RefSeq NM_198411 XM_006516223 XM_006516225
OMIM
CCDS CCDS36571
HPRD
IMGT
MGI ID MGI:1917685
MGI Symbol Inf2
EMBL AC124373
GenPept
RNA Seq Atlas 70435

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca