Version 5.4
Mus musculus Gene: Polk
Summary
InnateDB Gene IDBG-174450.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Polk
Gene Name polymerase (DNA directed), kappa
Synonyms Dinb1
Species Mus musculus
Ensembl Gene ENSMUSG00000021668
Encoded Proteins
IDBP-174452
polymerase (DNA directed), kappa
IDBP-174456
polymerase (DNA directed), kappa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122008:
External and internal DNA-damaging agents continually threaten the integrity of genetic material in cells. Although a variety of repair mechanisms exist to remove the resulting lesions, some lesions escape repair and block the replication machinery. Members of the Y family of DNA polymerases, such as POLK, permit the continuity of the replication fork by allowing replication through such DNA lesions. Each Y family polymerase has a unique DNA-damage bypass and fidelity profile. POLK is specialized for the extension step of lesion bypass (summary by Lone et al., 2007 [PubMed 17317631]).[supplied by OMIM, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:96480689-96542485
Strand Reverse strand
Band D1
Transcripts
ENSMUST00000022172 ENSMUSP00000022172
ENSMUST00000091387 ENSMUSP00000088950
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006261 DNA-dependent DNA replication
GO:0006281 DNA repair
GO:0006297 nucleotide-excision repair, DNA gap filling
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000122008
View Gene Order
ENSBTAG00000004028
Not yet available
Cross-References
SwissProt Q9QUG2
TrEMBL Q5Q9H6 Q5Q9H7 Q9CRV6
UniProt Splice Variant
Entrez Gene 27015
UniGene Mm.412455 Mm.413080 Mm.89926
RefSeq NM_012048 XM_006517680
OMIM
CCDS CCDS26704
HPRD
IMGT
MGI ID MGI:1349767
MGI Symbol Polk
EMBL AB027563 AB040765 AC122828 AC125534 AF163571 AK014087 AY769920 AY769921 BC052820
GenPept AAF02541 AAH52820 AAV80818 AAV80819 BAA86942 BAB29148 BAB59059
RNA Seq Atlas 27015

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca