Version 5.4
Mus musculus Protein: Polk
Summary
InnateDB Protein IDBP-174452.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Polk
Protein Name polymerase (DNA directed), kappa
Synonyms Dinb1;
Species Mus musculus
Ensembl Protein ENSMUSP00000022172
InnateDB Gene IDBG-174450 (Polk)
Protein Structure
UniProt Annotation
Function DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Note=Detected throughout the nucleus and at replication foci. {ECO:0000250}.
Disease Associations
Tissue Specificity Detected at low levels in heart, brain, lung, liver, kidney and testis. {ECO:0000269PubMed:10620008}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006261 DNA-dependent DNA replication
GO:0006281 DNA repair
GO:0006297 nucleotide-excision repair, DNA gap filling
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1349767
InterPro IPR001126 DNA-repair protein, UmuC-like
IPR006642 Zinc finger, Rad18-type putative
IPR017961 DNA polymerase, Y-family, little finger domain
IPR017963 DNA-repair protein, UmuC-like, N-terminal
PFAM PF00817
PF11799
PRINTS
PIRSF
SMART SM00734
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QUG2
PhosphoSite PhosphoSite-Q9QUG2
TrEMBL Q9CRV6
UniProt Splice Variant
Entrez Gene 27015
UniGene Mm.89926
RefSeq NP_036178
MGI ID 4FJO
MGI Symbol Polk
OMIM
CCDS CCDS26704
HPRD
IMGT
EMBL AB027563 AB040765 AF163571 AK014087 BC052820
GenPept AAF02541 AAH52820 BAA86942 BAB29148 BAB59059

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca