InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Scn2a1

Summary

InnateDB Gene

IDBG-174901.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scn2a1

Gene Name

sodium channel, voltage-gated, type II, alpha 1

Synonyms

6430408L10; A230052E19Rik; Nav1.2; Scn2a

Species

Mus musculus

Ensembl Gene

ENSMUSG00000075318

Encoded Proteins

IDBP-174894

sodium channel, voltage-gated, type II, alpha 1

IDBP-174903

sodium channel, voltage-gated, type II, alpha 1

IDBP-537114

sodium channel, voltage-gated, type II, alpha 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136531:
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is heterogeneously expressed in the brain, and mutations in this gene have been linked to several seizure disorders. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:65620857-65767447

Strand

Forward strand

Band

C1.3

Transcripts

ENSMUST00000028377	ENSMUSP00000028377
ENSMUST00000100067	ENSMUSP00000097645
ENSMUST00000144254	ENSMUSP00000117955
ENSMUST00000138368

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005248	voltage-gated sodium channel activity
GO:0005515	protein binding

Biological Process

GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0007399	nervous system development
GO:0008627	intrinsic apoptotic signaling pathway in response to osmotic stress
GO:0019228	neuronal action potential
GO:0034765	regulation of ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0051402	neuron apoptotic process
GO:0055085	transmembrane transport
GO:0086010	membrane depolarization during action potential

Cellular Component

GO:0001518	voltage-gated sodium channel complex
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0030315	T-tubule
GO:0030424	axon
GO:0033270	paranode region of axon

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000136531

View Gene Order

ENSBTAG00000038180

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_22266

Interaction between L1 and Ankyrins pathway

REACT_22205

L1CAM interactions pathway

REACT_111045

Developmental Biology pathway

REACT_18266

Axon guidance pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

110876

UniGene

Mm.220329

RefSeq

NM_001099298 XM_006498580 XM_006498581 XM_006498582 XM_006498583

OMIM

CCDS

CCDS38130

HPRD

IMGT

MGI ID

MGI:98248

MGI Symbol

Scn2a1

EMBL

GenPept

RNA Seq Atlas

110876