Version 5.4
Mus musculus Gene: Col17a1
Summary
InnateDB Gene IDBG-174965.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Col17a1
Gene Name collagen, type XVII, alpha 1
Synonyms BP180; Bpag; Bpag2
Species Mus musculus
Ensembl Gene ENSMUSG00000025064
Encoded Proteins
IDBP-174967
collagen, type XVII, alpha 1
IDBP-174969
collagen, type XVII, alpha 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000065618:
This gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:47646344-47692094
Strand Reverse strand
Band D1
Transcripts
ENSMUST00000026045 ENSMUSP00000026045
ENSMUST00000086923 ENSMUSP00000084141
ENSMUST00000151102
ENSMUST00000145254
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0031581 hemidesmosome assembly
Cellular Component
GO:0005581 collagen trimer
GO:0005604 basement membrane
GO:0016021 integral component of membrane
GO:0030056 hemidesmosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000065618
View Gene Order
ENSBTAG00000002430
Not yet available
Pathways
NETPATH
REACTOME
REACT_199045
Collagen formation pathway
REACT_199046
Assembly of collagen fibrils and other multimeric structures pathway
REACT_262098
Type I hemidesmosome assembly pathway
REACT_198984
Collagen biosynthesis and modifying enzymes pathway
REACT_206066
Extracellular matrix organization pathway
REACT_241978
Cell junction organization pathway
REACT_223082
Cell-Cell communication pathway
REACT_199052
Degradation of the extracellular matrix pathway
REACT_199055
Collagen degradation pathway
KEGG
mmu04974
Protein digestion and absorption pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_4
EGFR1 pathway
REACTOME
REACT_150180
Assembly of collagen fibrils and other multimeric structures pathway
REACT_121139
Collagen biosynthesis and modifying enzymes pathway
REACT_150401
Collagen degradation pathway
REACT_20537
Type I hemidesmosome assembly pathway
REACT_111155
Cell-Cell communication pathway
REACT_118779
Extracellular matrix organization pathway
REACT_20676
Cell junction organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
REACT_120729
Collagen formation pathway
REACT_206550
Collagen formation pathway
REACT_215758
Collagen biosynthesis and modifying enzymes pathway
REACT_223425
Extracellular matrix organization pathway
REACT_222620
Collagen degradation pathway
REACT_201925
Degradation of the extracellular matrix pathway
REACT_226104
Assembly of collagen fibrils and other multimeric structures pathway
REACT_214866
Cell junction organization pathway
REACT_206475
Cell-Cell communication pathway
REACT_207105
Type I hemidesmosome assembly pathway
KEGG
hsa04974
Protein digestion and absorption pathway
INOH
PID NCI
a6b1_a6b4_integrin_pathway
a6b1 and a6b4 Integrin signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.1225 Mm.398547
RefSeq NM_001290825 NM_007732 XM_006526626 XM_006526627 XM_006526628 XM_006526629
OMIM
CCDS CCDS38018 CCDS70959
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca