InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mid2

Summary

InnateDB Gene

IDBG-174979.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mid2

Gene Name

midline 2

Synonyms

FXY2; Trim1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000266

Encoded Proteins

IDBP-254829

midline 2

IDBP-254831

midline 2

IDBP-254833

midline 2

IDBP-537797

midline 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23438823

[Homo sapiens] MID2 was identified in a systematic screen for positive regulators of innate immune responses.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000080561:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures in the cytoplasm. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:140664599-140767715

Strand

Forward strand

Band

Transcripts

ENSMUST00000112993	ENSMUSP00000108617
ENSMUST00000112990	ENSMUSP00000108614
ENSMUST00000112988	ENSMUSP00000108612
ENSMUST00000128809	ENSMUSP00000123221
ENSMUST00000140144

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity
GO:0051219	phosphoprotein binding

Biological Process

GO:0016567	protein ubiquitination
GO:0032897	negative regulation of viral transcription
GO:0035372	protein localization to microtubule
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response
GO:0046597	negative regulation of viral entry into host cell
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:1902187	negative regulation of viral release from host cell

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005874	microtubule
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000080561

View Gene Order

Cross-References

SwissProt

Q9QUS6

TrEMBL

B1AVF4 B1AVF5 B1AVF6

UniProt Splice Variant

Entrez Gene

23947

UniGene

Mm.131097

RefSeq

NM_011845 XM_006528522 XM_006528523 XM_006528524

OMIM

CCDS

CCDS41151

HPRD

IMGT

MGI ID

MGI:1344333

MGI Symbol

Mid2

EMBL

AF196480 AL683809 BX470203 CH466616 Y18881

GenPept

AAF07340 CAB56170 EDL23932

RNA Seq Atlas

23947