InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mid2

Summary

InnateDB Protein

IDBP-254829.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mid2

Protein Name

midline 2

Synonyms

FXY2; Trim1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108617

InnateDB Gene

IDBG-174979 (Mid2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule-associated.

Disease Associations

Tissue Specificity

Low abundance in brain and lung, with even lower levels in heart, liver, and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0016567

protein ubiquitination

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005874	microtubule

Protein Structure and Domains

PDB ID

MGI:1344333

InterPro

IPR000315 Zinc finger, B-box
IPR001841 Zinc finger, RING-type
IPR001870 B30.2/SPRY domain
IPR003649 B-box, C-terminal
IPR003877 SPla/RYanodine receptor SPRY
IPR003879 Butyrophylin-like
IPR003961 Fibronectin, type III
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR018355 SPla/RYanodine receptor subgroup
IPR018957 Zinc finger, C3HC4 RING-type

PFAM