Version 5.4
Mus musculus Gene: Uba6
Summary
InnateDB Gene IDBG-175034.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Uba6
Gene Name ubiquitin-like modifier activating enzyme 6
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000035898
Encoded Proteins
IDBP-175036
ubiquitin-like modifier activating enzyme 6
IDBP-253999
ubiquitin-like modifier activating enzyme 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000033178:
Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin-activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE1L2 is an E1 enzyme that initiates the activation and conjugation of ubiquitin-like proteins (Jin et al., 2007 [PubMed 17597759]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:86110720-86172803
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000039373 ENSMUSP00000035328
ENSMUST00000113373 ENSMUSP00000109000
ENSMUST00000147734
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008641 small protein activating enzyme activity
GO:0016874 ligase activity
GO:0019780 FAT10 activating enzyme activity
Biological Process
GO:0006464 cellular protein modification process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000033178
View Gene Order
ENSBTAG00000006837
Not yet available
Pathways
NETPATH
REACTOME
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_230745
Immune System pathway
REACT_199115
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_229531
Adaptive Immune System pathway
KEGG
mmu04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt Q8C7R4
TrEMBL D3Z061
UniProt Splice Variant
Entrez Gene 231380
UniGene Mm.400233 Mm.400970 Mm.409339 Mm.486425
RefSeq NM_172712
OMIM
CCDS CCDS19378
HPRD
IMGT
MGI ID MGI:1913894
MGI Symbol Uba6
EMBL AC107634 AK049603 BC063048
GenPept AAH63048 BAC33836
RNA Seq Atlas 231380

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca