InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Chrna2

Summary

InnateDB Gene

IDBG-175063.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chrna2

Gene Name

cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)

Synonyms

Acra-2; Acra2; BC011490

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022041

Encoded Proteins

IDBP-175065

cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120903:
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence. [provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:66140960-66152948

Strand

Forward strand

Band

Transcripts

ENSMUST00000022620

ENSMUSP00000022620

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004889	acetylcholine-activated cation-selective channel activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0008144	drug binding
GO:0015464	acetylcholine receptor activity
GO:0042166	acetylcholine binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006812	cation transport
GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0034220	ion transmembrane transport
GO:0051291	protein heterooligomerization

Cellular Component

GO:0005892	acetylcholine-gated channel complex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0045211	postsynaptic membrane
GO:0071944	cell periphery