Version 5.4
Mus musculus Gene: Klf1
Summary
InnateDB Gene IDBG-175231.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Klf1
Gene Name Kruppel-like factor 1 (erythroid)
Synonyms Eklf; Nan
Species Mus musculus
Ensembl Gene ENSMUSG00000054191
Encoded Proteins
IDBP-175233
Kruppel-like factor 1 (erythroid)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105610:
This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:84901928-84905295
Strand Forward strand
Band C3
Transcripts
ENSMUST00000067060 ENSMUSP00000064366
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0001701 in utero embryonic development
GO:0001889 liver development
GO:0006338 chromatin remodeling
GO:0030218 erythrocyte differentiation
GO:0035162 embryonic hemopoiesis
GO:0043249 erythrocyte maturation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048821 erythrocyte development
GO:1901653 cellular response to peptide
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000105610
View Gene Order
ENSBTAG00000006083
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.4847
RefSeq NM_010635
OMIM
CCDS CCDS22483
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca