Version 5.4
| Mus musculus Gene: Dnase2a | |||||||||||
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| Summary | |||||||||||
| InnateDB Gene | IDBG-175257.6 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | Dnase2a | ||||||||||
| Gene Name | deoxyribonuclease II alpha | ||||||||||
| Synonyms | Dnase2 | ||||||||||
| Species | Mus musculus | ||||||||||
| Ensembl Gene | ENSMUSG00000003812 | ||||||||||
| Encoded Proteins |
deoxyribonuclease II alpha
deoxyribonuclease II alpha
deoxyribonuclease II alpha
deoxyribonuclease II alpha
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| Protein Structure | |||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
| InnateDB Annotation | |||||||||||
| Summary |
Dnase2a is required for Tlr9 activation by bacterial genomic DNA.
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| Entrez Gene | |||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105612:
This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||
| Type | Protein coding | ||||||||||
| Genomic Location | Chromosome 8:84908560-84922915 | ||||||||||
| Strand | Forward strand | ||||||||||
| Band | C3 | ||||||||||
| Transcripts | |||||||||||
| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||
| NETPATH | |||||||||||
| REACTOME |
Membrane Trafficking pathway
Lysosome Vesicle Biogenesis pathway
trans-Golgi Network Vesicle Budding pathway
Clathrin derived vesicle budding pathway
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| KEGG |
Lysosome pathway
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| INOH | |||||||||||
| PID NCI | |||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||
| NETPATH | |||||||||||
| REACTOME |
Lysosome Vesicle Biogenesis pathway
Clathrin derived vesicle budding pathway
trans-Golgi Network Vesicle Budding pathway
Membrane Trafficking pathway
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| KEGG |
Lysosome pathway
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| INOH | |||||||||||
| PID NCI | |||||||||||
| Cross-References | |||||||||||
| SwissProt | |||||||||||
| TrEMBL | S4R1G0 | ||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 13423 | ||||||||||
| UniGene | |||||||||||
| RefSeq | NM_010062 | ||||||||||
| OMIM | |||||||||||
| CCDS | CCDS22484 | ||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| MGI ID | MGI:1329019 | ||||||||||
| MGI Symbol | Dnase2a | ||||||||||
| EMBL | AC161765 | ||||||||||
| GenPept | |||||||||||
| RNA Seq Atlas | 13423 | ||||||||||