Version 5.4
Homo sapiens Gene: DNASE2
Summary
InnateDB Gene IDBG-31202.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNASE2
Gene Name deoxyribonuclease II, lysosomal
Synonyms DNASE2A; DNL; DNL2
Species Homo sapiens
Ensembl Gene ENSG00000105612
Encoded Proteins
IDBP-31204
deoxyribonuclease II, lysosomal
IDBP-762801
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 25600358
[Mus musculus] Dnase2a is required for Tlr9 activation by bacterial genomic DNA.
Entrez Gene
Summary This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:12875211-12881468
Strand Reverse strand
Band p13.13
Transcripts
ENST00000222219 ENSP00000222219
ENST00000588777
ENST00000592506 ENSP00000466912
ENST00000586547
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004520 endodeoxyribonuclease activity
GO:0004531 deoxyribonuclease II activity
Biological Process
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006259 DNA metabolic process
GO:0006308 DNA catabolic process
GO:0006309 apoptotic DNA fragmentation
GO:0030218 erythrocyte differentiation
Cellular Component
GO:0005622 intracellular
GO:0005764 lysosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003812
View Gene Order
ENSBTAG00000006082
Not yet available
Pathways
NETPATH
REACTOME
REACT_19287
Lysosome Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt O00115
TrEMBL A0A024R7F4 B7Z4K6 K7ENE5
UniProt Splice Variant
Entrez Gene 1777
UniGene Hs.118243
RefSeq NM_001375
HUGO HGNC:2960
OMIM 126350
CCDS CCDS12284
HPRD
IMGT
EMBL AB004574 AB008564 AC020934 AD000092 AF045937 AF047016 AF060222 AK297493 AK315358 BC010419 BC065209 BT007047 CH471106
GenPept AAB51172 AAC35751 AAC39852 AAC77366 AAH10419 AAH65209 AAP35696 BAA28623 BAB55598 BAG37753 BAH12592 EAW84320 EAW84322
RNA Seq Atlas 1777

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca