Version 5.4
Mus musculus Gene: Rgnef
Summary
InnateDB Gene IDBG-175452.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rgnef
Gene Name Rho-guanine nucleotide exchange factor
Synonyms 9230110L08Rik; AI323540; D13Bwg1089e; p190RhoGEF; Rgnef; RhoGEF; Rhoip2; RIP2
Species Mus musculus
Ensembl Gene ENSMUSG00000021662
Encoded Proteins
IDBP-262407
Rho-guanine nucleotide exchange factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000214944:
This gene encodes a member of the Rho guanine nucleotide exchange factor family. The encoded protein interacts with low molecular weight neurofilament mRNA and may be involved in the formation of amyotrophic lateral sclerosis neurofilament aggregates. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:97898595-98206165
Strand Reverse strand
Band D1
Transcripts
ENSMUST00000109426 ENSMUSP00000105053
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0021955 central nervous system neuron axonogenesis
GO:0032319 regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0060052 neurofilament cytoskeleton organization
Cellular Component
GO:0005737 cytoplasm
GO:0015630 microtubule cytoskeleton
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000214944
View Gene Order
ENSBTAG00000005633
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_111045
Developmental Biology pathway
REACT_228085
EPHB-mediated forward signaling pathway
REACT_18266
Axon guidance pathway
REACT_228170
EPH-Ephrin signaling pathway
KEGG
INOH
PID NCI
fak_pathway
Signaling events mediated by focal adhesion kinase
rhoa_reg_pathway
Regulation of RhoA activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.252718
RefSeq NM_012026 XM_006517518 XM_006517520 XM_006517522
OMIM
CCDS CCDS36758
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca