InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rgnef

Summary

InnateDB Protein

IDBP-262407.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rgnef

Protein Name

Rho-guanine nucleotide exchange factor

Synonyms

9230110L08Rik; AI323540; D13Bwg1089e; p190RhoGEF; Rgnef; RhoGEF; Rhoip2; RIP2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105053

InnateDB Gene

IDBG-175452 (Rgnef)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0021955	central nervous system neuron axonogenesis
GO:0032319	regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0060052	neurofilament cytoskeleton organization

Cellular Component

GO:0005737	cytoplasm
GO:0015630	microtubule cytoskeleton

Protein Structure and Domains

PDB ID

MGI:1346016

InterPro

IPR000219 Dbl homology (DH) domain
IPR001849 Pleckstrin homology domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00621
PF00169
PF00130
PF11929
PF12796

PRINTS

PIRSF

SMART

SM00325
SM00233
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite