Version 5.4
Mus musculus Gene: Synj1
Summary
InnateDB Gene IDBG-175516.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Synj1
Gene Name synaptojanin 1
Synonyms A930006D20Rik; AA675315; mKIAA0910
Species Mus musculus
Ensembl Gene ENSMUSG00000022973
Encoded Proteins
IDBP-400885
synaptojanin 1
IDBP-400882
synaptojanin 1
IDBP-531507
synaptojanin 1
IDBP-538671
synaptojanin 1
IDBP-540011
synaptojanin 1
IDBP-532277
synaptojanin 1
IDBP-625478
synaptojanin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159082:
This gene encodes a phosphoinositide phosphatase that regulates levels of membrane phosphatidylinositol-4,5-bisphosphate. As such, expression of this enzyme may affect synaptic transmission and membrane trafficking. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:90936092-91011308
Strand Reverse strand
Band C3.3
Transcripts
ENSMUST00000121759 ENSMUSP00000113308
ENSMUST00000118246
ENSMUST00000118390 ENSMUSP00000113518
ENSMUST00000154276 ENSMUSP00000122675
ENSMUST00000129041
ENSMUST00000129743 ENSMUSP00000123231
ENSMUST00000125032 ENSMUSP00000120399
ENSMUST00000130813 ENSMUSP00000119712
ENSMUST00000156140
ENSMUST00000170853 ENSMUSP00000128997
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0005515 protein binding
GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity
GO:0042578 phosphoric ester hydrolase activity
Biological Process
GO:0006836 neurotransmitter transport
GO:0007612 learning
GO:0016082 synaptic vesicle priming
GO:0016191 synaptic vesicle uncoating
GO:0046488 phosphatidylinositol metabolic process
GO:0046855 inositol phosphate dephosphorylation
GO:0046856 phosphatidylinositol dephosphorylation
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048488 synaptic vesicle endocytosis
GO:0048489 synaptic vesicle transport
Cellular Component
GO:0030117 membrane coat
GO:0030118 clathrin coat
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000159082
View Gene Order
ENSBTAG00000003063
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04070
Phosphatidylinositol signaling system pathway
mmu00562
Inositol phosphate metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121025
Synthesis of PIPs at the plasma membrane pathway
REACT_150352
Synthesis of IP2, IP, and Ins in the cytosol pathway
REACT_150312
Synthesis of IP3 and IP4 in the cytosol pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121175
PI Metabolism pathway
REACT_120870
Phospholipid metabolism pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
INOH
INOH website
Inositol phosphate metabolism pathway
PID NCI
erbb1_internalization_pathway
Internalization of ErbB1
ephbfwdpathway
EPHB forward signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.187079 Mm.396726
RefSeq NM_001045515 NM_001164483 XM_006522835 XM_006522842 XM_006522846
OMIM
CCDS CCDS49906 CCDS49907
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca