Version 5.4
Mus musculus Gene: Foxe3
Summary
InnateDB Gene IDBG-175595.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Foxe3
Gene Name forkhead box E3
Synonyms dyl; FREAC8; rct
Species Mus musculus
Ensembl Gene ENSMUSG00000044518
Encoded Proteins
IDBP-175597
forkhead box E3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186790:
This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. The protein encoded functions as a lens-specific transcription factor and plays an important role in vertebrate lens formation. Mutations in this gene are associated with anterior segment mesenchymal dysgenesis and congenital primary aphakia. [provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:114925147-114926013
Strand Reverse strand
Band D1
Transcripts
ENSMUST00000050940 ENSMUSP00000050445
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0008134 transcription factor binding
GO:0008301 DNA binding, bending
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001654 eye development
GO:0002089 lens morphogenesis in camera-type eye
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006590 thyroid hormone generation
GO:0007389 pattern specification process
GO:0030878 thyroid gland development
GO:0031069 hair follicle morphogenesis
GO:0043010 camera-type eye development
GO:0048468 cell development
GO:0048562 embryonic organ morphogenesis
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0060022 hard palate development
GO:0060023 soft palate development
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000186790
View Gene Order
Cross-References
SwissProt Q9QY14
TrEMBL
UniProt Splice Variant
Entrez Gene 30923
UniGene Mm.377122
RefSeq NM_015758
OMIM
CCDS CCDS18483
HPRD
IMGT
MGI ID MGI:1353569
MGI Symbol Foxe3
EMBL AF142647
GenPept AAF15997
RNA Seq Atlas 30923

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca