InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Foxe3

Summary

InnateDB Protein

IDBP-175597.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Foxe3

Protein Name

forkhead box E3

Synonyms

dyl; FREAC8; rct;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000050445

InnateDB Gene

IDBG-175595 (Foxe3)

Protein Structure

UniProt Annotation

Function

Transcription factor essential for lens epithelial proliferation and closure of the lens vesicle.

Subcellular Localization

Nucleus.

Disease Associations

Note=Defects in Foxe3 are the cause of the dysgenetic lens (dyl) phenotype. In mouse mutant dyl the lens vesicle fails to separate from the ectoderm, causing a fusion between the lens and the cornea. Lack of a proliferating anterior lens epithelium leads to absence of secondary lens fibers and a dysplastic, cataractous lens.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0008134	transcription factor binding
GO:0008301	DNA binding, bending
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001654	eye development
GO:0002089	lens morphogenesis in camera-type eye
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006590	thyroid hormone generation
GO:0007389	pattern specification process
GO:0030878	thyroid gland development
GO:0031069	hair follicle morphogenesis
GO:0043010	camera-type eye development
GO:0048468	cell development
GO:0048562	embryonic organ morphogenesis
GO:0050679	positive regulation of epithelial cell proliferation
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity
GO:0060022	hard palate development
GO:0060023	soft palate development