InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Olig2

Summary

InnateDB Gene

IDBG-175789.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Olig2

Gene Name

oligodendrocyte transcription factor 2

Synonyms

AI604895; Bhlhb1; bHLHe19; Olg-2; Oligo2; RK17

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039830

Encoded Proteins

IDBP-175791

oligodendrocyte transcription factor 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000205927:
This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:91225550-91228677

Strand

Forward strand

Band

C3.3

Transcripts

ENSMUST00000035608

ENSMUSP00000036797

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046983	protein dimerization activity
GO:0071837	HMG box domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007399	nervous system development
GO:0021522	spinal cord motor neuron differentiation
GO:0021529	spinal cord oligodendrocyte cell differentiation
GO:0021530	spinal cord oligodendrocyte cell fate specification
GO:0021794	thalamus development
GO:0042552	myelination
GO:0045665	negative regulation of neuron differentiation
GO:0048663	neuron fate commitment
GO:0048709	oligodendrocyte differentiation
GO:0048714	positive regulation of oligodendrocyte differentiation

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000205927

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_5

ID pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.37289 Mm.405277

RefSeq

NM_016967

OMIM

CCDS

CCDS28323

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas